影片以中国家喻户晓的湖北神农架野人的传说为故事核心元素，试图还原野人的神秘形象。影片讲述了一位在中国担任家庭女教师的美国大学生与她的学生乘坐的飞机遇险，迫降神农架原始森林，随着他们与野人发生神秘呼应，一连串惊心动魄的事情接连发生??为了保护野人，他们与盗猎集团展开层层惊险且充满智慧的周旋、较量，最终正义战胜邪恶，而人性的善与恶也在这过程中得以深入展现并引人思考。
陈大文（梁朝伟 饰）有一名拍拖十年之久的女友（刘锦玲 饰），两人将近结婚。他与好友程仁（梁家辉 饰）、毛周朱（郑丹瑞 饰）住在一起。每个晚上程仁都会带不同女生回家，毛周朱则胆小如鼠，不敢与女性交往。
Based on the internationally best-selling novel by Jonas Jonasson, the unlikely story of a 100-year-old man who decides it's not too late to start over. For most people it would be the adventure of a lifetime, but Allan Karlsson's unexpected journey is not his first. For a century he's made the world uncertain, and now he is on the loose again.
